canvas: "Scientific Editorial Infographic" global_style: "Ultra-realistic 3D, precise macro lighting, shallow DOF, structural biology aesthetic" title: "FOLD: THE ENERGY LANDSCAPE OF [$PROTEIN]" layout_engine: type: "Multi-Basin Free-Energy Landscape" connectors: "Conformational transition paths with Gibbs gradient contours" frame_shape: "Funnel + side-basin topology (native basin + kinetic traps)" flow_direction: "High-entropy ensemble → folded basin(s) → off-pathway kinetic traps" frames: f1_unfolded: size: "xs" content: "Semantic inference of [$PROTEIN] unfolded ensemble: heterogeneous, high-entropy conformers" ui_label: "Unfolded | High entropy | Conformational ensemble" f2_secondary: size: "s" content: "Semantic inference of [$PROTEIN] early local structure formation: transient helices, sheets, turns" ui_label: "Secondary | Local structure | Backbone H-bond emergence" f3_intermediate: size: "m" content: "Semantic inference of [$PROTEIN] folding intermediates: partially collapsed, non-native contacts" ui_label: "Intermediate | Molten-globule | Multi-pathway basin" f4_native: size: "l" content: "Semantic inference of [$PROTEIN] functional conformation: stable basin, correct topology" ui_label: "Native | Functional basin | Lowest accessible ΔG" f5_misfolded: size: "xl" content: "Semantic inference of [$PROTEIN] off-pathway misfolding: β-rich aggregates, fibrils, or amorphous states" ui_label: "Misfolded | Kinetic trap | Off-pathway aggregation" side_panel: "RMSD-to-native trends, ΔG basin depths, structural icons (helix, sheet, loop, aggregate), pathway arrows" halo_details: "Ramachandran overlays, hydrophobicity heatmaps, phi/psi distributions, frustration hotspots. Reject generic DNA helices, pill bottles, or non-protein artifacts."